Dept. of Health Research Govt. of India
World Health Organization
Name of the Project National Hospital Based Rotavirus Network Project
Principal Investigator Dr. Sanjay Mehendale (Coordinator)
Co-Principal Investigator(s) Dr. C.P.Girish Kumar, Dr. S. Venkatasubramanian
Other Investigator(s) Rotavirus surveillance network group
Collaboration / Participating Centers

Coordinating center- NIE

Referral centers- NIV, CMC, NICED, AIIMS

Regional centers- RMRCs at Port Blair,Jabalpur, Dibrugarh, Belgaum, Bhuvaneshwar & RMIMS Patna

Peripheral centers- 32 hospital sites across the country
Funding Agency / Sponsor ICMR
Budget NIE Budget : ~2.3 crores / 4 years, Overall Budget-: ~28 crores / 4 years
Study Period 4 years (2012-2016)
  • To establish a national hospital based surveillance to examine long term trends and pattern of diarrhea attributable to rotavirus among children < 5 years of age seen at in-patient facilities
  • To determine the age, seasonal distribution and outcomes of rotavirus-associated disease among the population under surveillance, including monitoring trends over time.
  • To investigate the molecular epidemiology of rotavirus in India by typing the G and P type and characterization of untypable strains by sequencing.
  • To estimate the economic burden of rotavirus gastroenteritis seen at hospitals by standardized costing studies.
Description All children less than 5 years of age presenting with diarrhoea will be enrolled after obtaining informed and written consent from the parent/guardian. Clinical information and a stool specimen will be obtained from each enrolled child. The stool sample will be tested for the presence of rotavirus by ELISA. Rotavirus positive stool specimens will be further characterized to determine the G and P types of strains using a variety of molecular methods, including muliplex RT-PCR and specific priming and PCR for specific genotypes. Quality assurance excercises will be conducted periodically.
Quarterly Reports (5-10 lines) Surveillance is in progress in 9 CRS from September 2012
Significant achievements NA