National Institute of Epidemiology, Chennai
1997-2011Capacity building initiatives in epidemiology and public
- In 2001,
initiated a two-year, competency based Master of Applied Epidemiology-Field
Epidemiology Training Programme for in-service medical officers working with
state health departments. During 2001-10, trained more than 100 candidates from
18 Indian states. Several of the graduates
are holding key positions in disease surveillance and other public health
programmes in different states.
- The ICMR School
of Public Health at NIE started its Master of Public Health (MPH) programme in
July 2008 in order to address the acute shortage of trained public health human
resources in the country.
- Conducted controlled,
double blind, randomized prophylactic leprosy vaccine trial in Chingleput
district, Tamil Nadu, 1993-2002 with 171,400 leprosy-free volunteers vaccinated
with one of the four vaccines (BCG, BCG+ killed M. leprae, Mycobacterium w and
ICRC) or placebo
- Conducted WHO-sponsored
controlled trials of single dose of Rifampicin, Ofloxacin, Minocycline (ROM)
for treatment of paucibacillary leprosy that demonstrated comparable efficacy
of ROM to WHO-MDT for six months.
- Co-ordinated WHO-TDR
supported, multi-centric trial of Uniform multi-drug therapy (U-MDT) for all
pauci and multi-bacillary leprosy patients which indicated promising interim
results with respect to clinical status of skin lesions and low level of
Bio-statistical Monitoring Unit (CBMU) conducted multi-centric trials for six
disease conditions including trials on Ksharasootra
for fistula-in-ano and Vijayasar for
type 2 diabetes.
- Multi-centric bridging
study on Intradermal administration of tissue culture Anti Rabies Vaccines
(Abhayrab PVRV, Coonoor PVRV, Rabipur PCECV) that found a sustained immune
response above the protective level and were recommended for use as
post-exposure prophylaxis of animal bites in India.
- Initiated cohort
study for cardiovascular risk factors in a rural population in Tamil Nadu
covering more than 10,000 adults residing in 11 villages of Kancheepuram and
Thiruvallur districts of Tamil Nadu in 2005-07.
- Established the
cohort of injection drug users in Chennai determine the effect of HIV,
co-morbidities, HAART use and drug use on nutritional and metabolic
abnormalities among IDUs in Chennai.
- Estimated the
risk of disability among leprosy patients after release from treatment (3.24
per 100 person-years among MB patients and 0.2 per 100 person years among PB
surveys and managed the data for Integrated behavioral and biological
Assessment (IBBA): Rounds 1 (2006) and 2 (2009), Tamil Nadu among the high risk
groups (HRGs) in five Avahan districts of Tamil Nadu. Round 1 estimates along
with data from other sources such as NFHS and HSS contributed to the revision
of the estimated number of persons living with HIV in India.
- Estimated the prevalence of sexually transmitted infections and sexual practices among the injection drug users in Chennai and their regular sex partners.
- Conducted a
mixed methods cross-sectional survey in Namakkal district of Tamil Nadu to
estimate the HIV/HSV2 prevalence and associated risk factors among truck
drivers and their wives and demonstrated feasibility and acceptability of audio
computer-assisted interview (ACASI) system for collecting sensitive data from
poorly literate, non-English speaking, mostly rural populations of women and
men in India.
Health Systems Research
study of Cardiovascular disease risk factors among industrial workers in
- Pilot study in restaurants and educational institutions in Chennai and Vellore districts in Tamil Nadu that demonstrated poor compliance to the tobacco-free law.
- Evaluated the
clinic based hypertension screening and treatment in the Primary Health centers
and government hospitals to assess hypertension control rates and awareness
about life style modification among patients with hypertension in the
Virudhunagar and Sivagangai districts in Tamil Nadu and demonstrated
feasibility and effectiveness of hypertension management in the public sector
facilities leading to scale-up to entire state.
Comprehensive Emergency Obstetric and newborn care (CEmONC) centres of Tamil Nadu and identified certain
gaps in terms of availability of health care personnel particularly
specialists, which led to an increase in women referred out of the CEmONC
- Evaluated the
pilot project of cervical cancer screening at the primary care level being
implemented by the Tamil Nadu Health Systems Project in Thanjavur and Theni
districts and demonstrated the feasibility of using visual inspection as a
screening tool for cancer cervix at primary care level.
- Coordinated the
multi-centric, hospital based surveillance for rotavirus disease among
under-five children in 10 hospitals in 7 different regions of India.
solutions to problems in the use of Geographical Information System in Public
Health through series of workshops in 2011-12.
- Developed a new
approach " Reverse Tracking Method” to estimate the size of High risk
population for HIV.
- Identified an
alternative approach to analyze data collected by respondent driven sampling
modules for systematic outbreak investigations.
- Developed a simulation
mathematical model for leprosy (SIMLEP) to project epidemiologic trends over
time, producing output on indicators such as prevalence, incidence and
case-detection rates of leprosy.
usefulness of lot quality assurance sampling for leprosy elimination monitoring
under field conditions.